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Alessandro Prigione Profile picture
Alessandro Prigione
@AlePrigio
iPSC scientist and Prof in Pediatric Metabolic Medicine. Hoping to find cures for rare mitochondrial diseases. He/him
Mar 26, 2021 • 16 tweets • 7 min read
I am super excited to share our latest work!!

We developed a human model of Leigh syndrome with brain organoids. Thread below.
Led by @GizCicada with @N_Rajewsky

@MDC_Berlin, @HHU_de, @MedHHU, @StemCellsNRW, @SpringerNature, @NatureComms

Full text: rdcu.be/chxc4 Leigh syndrome is a #RareDisease caused by #mitochondria defects, causing neurodevelpmental impairment and early death. No treatments are available . SURF1 mutations are a main cause but animal models do not recapitulate clinical features.