Anil Makam Profile picture
#UCSF #HospitalMedicine Physician Researcher at #SFGH || Research in outcomes & health services || #EBM advocate, but not in the usual sense
Nov 22, 2024 9 tweets 2 min read
We are prescribing way too much cancer therapy to people with very advanced cancers with poor prognosis and its harming people and wasting money

Thread Thesis: immunotherapy & targeted cancer therapy do NOT revolutionize care for everyone

Trials only include healthier patients who can walk & still work

We are applying this evidence to people who can't take care of themselves or get out of bed

Leads to BAD care

Example
Oct 25, 2024 10 tweets 3 min read
He's right

the cases selected are a tiny sliver

Most of inpatient medicine are the common ailments & scenarios we don't discuss

They would make for amazing morning report cases if you broke it down the same way

here is a current case I'm thinking thru older lady with vascular dementia & osteoporosis with acute on chronic LBP with new T12 compression fracture with bad pain

she is confused, nonverbal, writhing, grimaces, winces when you push her T12 spinal process
Aug 27, 2024 8 tweets 3 min read
We started a #NewsYouCanUse lecture series for our Division

Here are 6 bite-sized evidence based pearls to consider incorporating into your practice & teaching

Links in QR code 1. Use pip-tazo extended infusion for empiric therapy IF worried about pseudomonas

I can now prescribe it again without the hoops & hurdles of ID approval!

@DrToddLee @dralicehan Image
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Oct 23, 2023 23 tweets 5 min read
Finished a brief stint on the faculty hospital medicine service in a safety net hospital

Lots of skin/soft tissue infections, addiction, & inability to care for self

Run down of every single patient I saw with a teaching pearl (or two)

I saved the best for last 1| AUD intoxication->fall->inability for self care

system pearl 🦪: there's a real donut hole in the safety net (& many hospitals frankly) for patients who don't have acute rehab needs, but need custodial care in the short term

what I do know is they don't need to see me daily
Oct 18, 2023 15 tweets 6 min read
Wow

Just read perhaps the greatest article about a doctors’ diagnostic skills

Not in the medical literature, but in an economics journal!

If you think about diagnosis, follow along

It won’t disappoint

@RogueRad 1| THE ISSUES

Diagnostic test thresholds have an inherent sensitivity/specificity tradeoff

But if the test involves doctoring (ie history or exam finding) is this tradeoff still true?
Aug 7, 2023 16 tweets 3 min read
5 cases I reflected on after a 5 day stint on service in the hospital 1A. Pt with AUD & freq falls was still orthostatic after 3L IVF & attributed possibly to dysautonomia

But HR change was ~30 beats with much less dramatic BP drop

ΔHR/ΔSBP >>> 0.5 so very c/w low preload (here hypovolemia)

Did better with more IVF

pubmed.ncbi.nlm.nih.gov/29405350/
Dec 16, 2022 14 tweets 6 min read
It’s that time of year

Here are my top 12 studies from 2022 in no particular order that influence Hospital Medicine

I avoided:
-only abstracts (sorry SABATO & TRANSFORM-HF)
-COVID since the disease as we once knew it is uncommon
-Subspecialty or critical care only implications For agitated delirium it’s safe to treat with haloperidol & probably also saves lives

This upends what I thought I knew about delirium treatment

nejm.org/doi/full/10.10…

Dec 15, 2022 7 tweets 4 min read
Phenomenal must read piece by @awgaffney on the power & peril of intensive care

As stated, LTACHs are emblematic of this

Some reflections from our research... LTACHs are the 'afterworld' of the ICU as @paula_span coined it

nytimes.com/2019/09/13/hea…
Sep 12, 2022 25 tweets 6 min read
I shared my experience to celebrate remarkable progress

I apologize for my tweet, which was flippant in its implications since it was clumsily worded and lacked context

Many chose to assume the worst—such is life

A longish thread if you will let me Many of you who engaged with this tweet don’t know me and have not been following me since chapter 1 of the pandemic

Here are my disclaimers

Jun 21, 2022 15 tweets 4 min read
1| This thread is for other parents who are also deciding about #COVID vax for their toddlers (2-4 yo) who have ALREADY had Omicron

TLDR: Will wait to see: 1) vax effectivness vs BA4/5; 2) whether new vax to O variants available; 3) most importantly, how day care policies evolve 2| Disclaimers:

-I believe COVID mRNA vax for adults is among the most remarkable scientific innovations in our history

-I am vaxxed with pfizer x3 (and my DNA hasn't been altered)
Sep 3, 2021 25 tweets 8 min read
The community masking trial in Bangladesh by @Jabaluck @mushfiq_econ et al is AMAZING & EXCEPTIONALLY well done

Joy to read & I learned a LOT

Encourage all scientists in related disciplines to read, even if not your content

Thread on study

poverty-action.org/publication/im… 2| DISCLAIMERS FIRST

1. I apply this same scientific lens to all health care & pharma trials I find interesting

2. Most relevant & needed to LMIC. But I will also take a US lens on how this may apply

I understand this is a hot button, or should we say, a hot mask issue
Apr 6, 2020 11 tweets 3 min read
Attended on the Hospitalist #COVID service for 3 days at #ZSFG. Thread on reflections as a safety-net hospitalist

Don't worry, unlike making lemonade from lemons, I will not make evidence out of limited anecdotal experience 2| For context

In SF as of April 5th we have 529 COVID19+ patients with 8 deaths (aka not close to NYC)

At ZSFG, we have 26 admitted patients, with 16 in the ICU

No overt shortages, though we are conserving faceshields & N95 masks between COVID19 patients
Aug 27, 2018 11 tweets 6 min read
1| Good #cardiotwitter on #SCOTHeart. Others have tweeted reasons y believable. Here is my reply tweetorial

@khurramn1 @AChoiHeart @MarcDweck @JWeirMcCall @rwyeh @drjohnm @venkmurthy @DavidLBrownMD @RogueRad
#ESCCongress
Linking my original tweetorial:
2| Let's start with MI def. Billing codes less accurate than adjudicated MI outcomes, yes? Could be nondiff misclassification which bias to null. But could also be diff w/ ascertainment bias (look harder, anchoring) knowing CCTA result, since 2/3rds normal or nonobstruct.
Aug 25, 2018 12 tweets 6 min read
1| follow for my critical appraisal tweetorial of #SCOTHEART trial in @NEJM #ESCCongress

Basics: RCT of upfront CTA vs standard of care for stable CP referred to Scottish cardiology clinics. 1.6% fewer had primary outcome with CTA

nejm.org/doi/full/10.10… 2| more basics: primary outcome is driven by nonfatal MI, not death. Authors did tremendous job at highlighting this

#ESCCongress #SCOTHEART