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MosheArditiMD Profile picture
MosheArditiMD
@ArditiMd
Prof of Pediatrics and Biomedical Sciences Cedars Sinai Medical Center. Los Angeles. Director, Division of Pediatric Infectious Diseases and Immunology
Sep 28, 2020 • 14 tweets • 4 min read
Ivet Bahar and our labs with the brilliant scientists in both labs worked very hard for this paper. pnas.org/content/early/… 1- SARS-CoV-2 spike harbors a high affinity site for TCR β-chain binding, which contains an insertion, P681RRA684, unique to SARS2. @EricTopol #COVID19 2- Comparison to other β-CoV S sequences showed that SARS-CoV-2 S is distinguished by the existence of this 4-residue insertion, PRRA, preceding the S1/S2 cleavage site (R685-S686 peptide bond) (Fig.2A). The insertion PRRA and sequence similarities to those of neurotoxins Fig.2D.