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Bettina Weigelin Profile picture
Bettina Weigelin
@BettinaWeigelin
Scientist, Multiscale Immunoimaging, Werner Siemens Imaging Center, University Hospital Tübingen
Sep 12, 2021 • 17 tweets • 8 min read
It’s exciting to finally share and discuss our study on additive cytotoxicity, a crowd-based killing mechanism of cytotoxic T cells (CTL) to target cancer!
Highlights in the thread, free access @NatureComms here: nature.com/articles/s4146…
1/17
#immunology #microscopy Initially, we aimed to study modulators of CTL serial killing capacity. But live-cell imaging of various mouse and human model systems, incl. OT1 CTL targeting OVA-expressing cancer cells surprisingly showed, that CTL are pretty bad killers and most contacts were non-lethal. 2/