Immunologist & macrophage biologist. Macrophage-pathogen interactions, atherosclerosis, and protein diffusion. I 💖🔬. I also 💖 🐝, 🐐, 🧀 & 🍺
Feb 11, 2023 • 10 tweets • 5 min read
Excited to present my labs latest pre-print, in which we uncover one of the mechanisms used by #SARS-CoV-2 to evade the #ImmuneSystem. A short tweet-torial on what we found 1/10 biorxiv.org/content/10.110…
Innate immune cells respond first to infection, often by "eating" pathogens. This slows infection, but full clearance often requires adaptive immunity - as in the antibodies and T cells that respectively neutralize pathogens and kill pathogen-infected cells. 2/10
Aug 29, 2020 • 18 tweets • 11 min read
@postcovid_CH@AdrianoAguzzi T cells aren't an "alternative" form of immunity. Their role is tightly entwined with all immune responses, and in fact, you can't really make antibodies to a pathogen without *first* activating T cells. /thread
@postcovid_CH@AdrianoAguzzi When you are infected (or get a vax; your immune system doesn't know the difference), the first thing that happens is the pathogen is recognized by "innate" immune cells. These "see" pathogens by recognizing molecules common across multiple pathogens /2