Discover and read the best of Twitter Threads about #SARS

Most recents (24)

1-#COVID19 her ne kadar çocuklarda erişkinlere göre daha hafif seyirli olsa da, ekonomik koşullarının dezavantaj yarattığı coğrafyalarda, çocukların bu hastalıktan daha az etkilenmesi için önlemler şart. BMJ Global Health’de yeni yayınlanan makaleyi özetlemeye çalıştım: Image
2-Bu çocuklarda hayati öneme sahip, oksijen, antibiyotik, kişisel koruyucu ekipmanların sağlanması; rutin aşılama, doğum ve doğum sonrası bakım, emzirme ve daha sonrasında beslenmenin desteklenmesi, HIV ve sıtma için profilaksi ve tedavinin sağlanması kritik.

📸 #UNICEF Image
3-Tüm bu desteklerin sağlanması ve tedarik de yaşanacak tüm aksaklıkların giderilmesi (ki bunun pandemi ile ilgili alakası yok, her zaman olması gereken insani hakları), yoğun bakım koşullarının iyileştirilmesinden çok daha fazla yaşamı kurtaracağı düşünülüyor.

📸 #UNICEF Image
Read 8 tweets
1/5 Was a great pleasure to collaborate with Grigory Efimov's @grigory_efimov lab on the analysis of T-cell repertoires in #COVID-19 patients, identifying public T-cell responses to #SARS-CoV-2 antigens in #COVID-19-exposed donors. Main findings of […] are:
2/5 While anti-#SARS-CoV-2 antibody levels can tell convalescent patients from healthy ones, T-cells can distinguish both convalescent patients and donors sampled during #COVID-19 pandemic from control donors sampled pre-pandemic.
3/5 Tetramer-sorting reveal hundreds of TCRs specific to two #SARS-CoV-2 epitopes, A*02:YLQ and A*02:RLQ. These TCRs display conserved motifs shared across patients. Short CDR3s and restricted gene usage suggests that epitope recognition is both germline-encoded and public.
Read 5 tweets
📣 Starting this afternoon at 3:30 pm PST! Science journalist and @NPR science correspondent Richard Harris (@rrichardh) will be joining the latest #CovidTownHall in our series to discuss science reporting during a pandemic with @ucdavis students. You don't want to miss this!
Richard Harris has covered science, medicine and the environment for @NPR since 1986. His award-winning work includes reports in 2010 that revealed the US Government was vastly underestimating the amount of oil spilling from the Macondo blowout in the Gulf of Mexico. #journalism
He also shared a @PeabodyAwards with colleague Rebecca Perl for their 1994 reports about the tobacco industry’s secret documents, which showed that company scientists were well aware of the hazards of smoking. #journalism #reporting #sciencejournalism
Read 51 tweets
Promised to tweet out a few more thoughts from my reporting on #covid19 clustering and dispersion factor k. So here goes:
Quick recap first: Reproduction number R is an average. R = 3 does not mean every person infects three others. It’s more like busses that “come” every 10 minutes and you end up waiting 30 minutes and 3 come along.
In reality some people infect a lot of people and most people infect no-one. That’s particularly pronounced in coronaviruses like SARS. In his 2004 Nature paper @jlloydsmith estimates that in Singapore before control measures 2/3 of people with #SARS did not transmit at all.
Read 15 tweets
"The live SARS-like coronavirus SL-CoV-WIV1 has been isolated for the first time from bat droppings; and such virus has been confirmed to invade the host cells through the ACE2 of human beings..." ImageImageImage
Bat Severe Acute Respiratory Syndrome-Like Coronavirus WIV1
Encodes an Extra Accessory Protein, ORFX, Involved in Modulation of the Host Immune Response. (2016) #ZhengLiShi #PeterDaszak #EcoHealth
Funding: #NIAID 110964 ImageImageImageImage
In this study, we have developed a fast and cost-effective method
for reverse genetics of coronaviruses by combining two approaches developed by others..As the genomes can be divided into multiple short fragments, mutations can be introduced into individual
fragments easily. ImageImageImageImage
Read 66 tweets
Mwanasayansi mwenye ubobezi wa kimataifa kwenye maswala ya vitendanishi na vipimo (Diagnostics), Dr. Ally Mahadhy, aliandika haya kwenye ukurasa wake wa facebook, ni vyema wadau humu wakayapata ili kuongeza uelewa @Udadisi
@MariaSTsehai @fatma_karume
Uzi 👇🏽
"Kutakucha tu!

Tukiwa tupo kwenye taharuki juu ya kipimo cha corona (covid-19) hapa nchini, baada kutoa majibu ya positive kwa mbuzi na papai, naomba nitoe maoni yangu kama mdau katika tansia hii ya vitendanishi vya maabara (diagnostics). ..." /1
Nianze kwa kutangaza maslahi yangu binafsi kwenye mada husika. Mimi ni mtafiti kwenye eneo hili la vitendanishi (Medical and clinical diagnostics). Tasnifu (thesis) yangu ya umahiri (MSc in Biotechnolgy) iljikita kwenye kutengeneza njia (method) ya kutambua kwa haraka na wepesi/2
Read 61 tweets
Millions of children worldwide have already been exposed to #SARS-COV-2; hospitalizations and deaths are vanishingly low. Yet, suddenly, just as the media and lockdown governors need a new reason to panic people, New York state@reports three child deaths “related to” #COVID...
“Related” how? Who knows? Some of the kids (and others who were hospitalized but fortunately didn’t die) had an active infection; some had antibodies; some had neither. Did they have other serious medical conditions? Nobody is saying...
Is there a plausible or even implausible mechanism of action here? Your guess is as good as @NYGovCuomo. No matter, this is all the excuse anyone needs to keep camps closed all summer... and maybe even schools in the fall. Wait for it.
Read 3 tweets
The #CCPCoverUp led to a #Pandemic that now threatens the lives of people around the globe. See through the deception, and keep yourself and your family truly informed. (Thread👇)

Let's reject the #CCP.

Sign the petition:
The #CCPLied about the origin of the outbreak and covered it up, costing the world 6 valuable weeks of preparation.

The #CCPVirus started in central #China, and might have been contained there—but instead, it was allowed to spread, creating a #GlobalPandemic.
Unfortunately, the #CCPVirus is only the tip of the iceberg.

For decades, the #CCP has been actively undermining the economies, #NationalSecurity, and moral fabric of nations around the world.

Sign the petition:
Read 11 tweets
#Remdesivir begins distribution in the #USA today via #EUA.

I thought would write down some practical #tips based on my #qualitative anecdotal experience after personally treating close to 200 patients with #COVID19.

For quantitative results, wait for the papers¬—thread
“this juice works, doc!” When you hear similar expressions 1-2 days after starting #remdesivir multiple times, you start to wonder. Don't recall a similar proportion of patients smile after feeling so sick 1-2 days earlier with #COVID19. x/n? Wait for the papers.
Like #treatment for any severe infectious disease (meningitis, Gram-negative bacteremia, influenza pneumonia, etc), earlier is always better. #COVID19 is no different. #Remdesivir stops #SARS-CoV2 replication, but won’t heal the lung injury.
Read 13 tweets
La única salida real a la epidemia de #COVID-19 es lograr lo que se conoce como ‘inmunidad de grupo o rebaño’ (herd immunity) contra #SARS-CoV-2, el virus que causa le enfermedad que conocemos como COVID-19

Pero ¿cómo y en cuánto tiempo podríamos lograrlo en Chile?

Abro hilo...
¿Qué es la inmunidad de grupo?

Cuando la mayoría de la población es inmune a una enfermedad infecciosa, esto proporciona protección indirecta, a aquellos que no son inmunes a la enfermedad.
Poee ejemplo, dependiendo de cuán contagiosa sea una infección, generalmente del 70% al 90% de una población necesita inmunidad para lograr la inmunidad del rebaño.
Read 15 tweets
1/ #Ebola RNA was found in the aqueous humor of the eye, and persistence was describe in the CNS, #placenta, and in semen up to 565 days post-acute EVD, highlighting the need to investigate the parameters of EBOV clearance from immune-privileged organs.…
2/ Case series from prior epidemics report an 89%–93% case fatality rate among pregnant women, and perinatal mortality is 100%. No reports have been published of neonates surviving trans-placental #Ebola Virus Disease for longer than 19 days. (😮🤯)
3/ Maternal immunoglobulins M are poorly transported through placental villi and the fetal secretory immune system starts producing immunoglobulin M around the 20th week of gestation.…
Read 18 tweets
Lots of colleagues & friends remain sore after the #FauciLeak on the interim #ACTT trial analysis that compared #remdesivir to placebo in patients hospitalized with severe #COVID19 2 days ago.

My thoughts on the events as a #clinicaltrials and #DSMB doctor—thread 1/10
Data Safety Monitoring Boards (#DSMB) are independent groups of doctors & statisticians that analyze unblinded data in clinical trials, key to assure safety of patients enrolled, think about it as a safety satellite or control tower for the blinded investigators & patients.
#DSMBs have an instruction set (charter) agreed on before the #trial starts, includes prespecified statistical analyses (very low p-values) and thresholds that would trigger stopping a trial early for efficacy (big beneficial effect), toxicity (harms), futility (wasting our time)
Read 12 tweets
@Nomdeplumi1 @uTobian @R_H_Ebright The general public is shocked I tell you shocked that #Coronavirus RNA *might* have been combined with #HIV RNA! Could it be?!? Well yes, we’ve been publishing about it in peer reviewed journals for years.
@Nomdeplumi1 @uTobian @R_H_Ebright #HIV Lentiviral vectors are regularly used in #Coronavirus research
@Nomdeplumi1 @uTobian @R_H_Ebright An #HIV lentiviral vector includes these elements in the final diploid RNA strands:
1 The RNA from #Coronavirus
2 The reporter gene: Luciferase (LUC)
3 #HIV Long Tandem Repeats (LTRs) to integrate the DNA in the target DNA
4 #HIV Psi-sequence to package RNA in viral particles
Read 13 tweets
We’ve prepared a short report on the early introductions and spread of #SARS-CoV-2 in the northern regions of France…. Find some key messages below. #COVID19 (1/9)
Several early introductions to France do not appear to have led to further spread likely due to effective contact tracing and isolation. (2/9)
Most sequences from France are spread out in the diversity of clade G (@GISAID nomenclature). This represents local circulation with possibly multiple introductions, and one export to Algeria. (3/9)
Read 10 tweets
World Economic Forum: "Lockdown is the world's biggest #psychological #experiment - & we will pay the price"

Apr 9 2020 "With some 2.6 billion people around the world in some kind of #lockdown, we are conducting arguably the largest psychological experiment ever"

"Unfortunately, we already have a good idea of its results. In late Feb 2020, right before EU countries mandated various forms of lockdowns, The Lancet published a review of 24 studies documenting the #psychological impact of quarantine."

"The findings offer a glimpse of what is brewing in hundreds of millions of households around the world...

people who are #quarantined are very likely to develop a wide range of symptoms of #psychological #stress and #disorder..."

Read 14 tweets
A #thread on the origin of the Severe Acute Respiratory Syndrome #coronavirus-2 #SARSCoV2, the #virus causing #COVID19. SARS-CoV-2 was identified early January 2020; genetic sequence shared publicly on 11 January. #scicomm [image 감사합니다 @IBS_media] @Virologist_11 @dirgarambe
Full genetic sequence of #SARSCoV2 from early human cases & sequences of other virus isolated from human cases from China & all over the world since then show that SARS-CoV-2 has an ecological origin in #bats.
All available evidence to date suggests that #SARSCoV2 #coronavirus has a natural animal origin and is not a manipulated or constructed virus.…
Read 8 tweets
I've identified the 4 main universities/hospitals and key players behind the worldwide fake #COVID19 #scamdemic.
1. #JohnsHopkins, Baltimore
2. #ErasmusMC, Rotterdam
3. #Charité, Berlin
4. #AixMarseille Université, Marseille.
Here the numbers and the science is invented for you.
1. The #Bloomberg funded and media trained #JohnsHopkins school brings us all #corona numbers. They invent how many people live or die worldwide, and often also nationally. They know first and best somehow. Magic! - #WHO's #COVID19 main man #BruceAylward, and many others are JH.
2. #ErasmusMC Rotterdam. Running not only literally all Dutch news on the non-existing #coronavirus, but they control #corona intellectual property. Time 2012 Top 100 Influential person Ron Fouchier, Ab Osterhaus, and their crew have patents on treatment, diagnosis, prevention.
Read 9 tweets
I was feeling overwhelmed by all the laypress articles about #moralinjury and #burnout in frontline health care workers during #Covid_19 so I decided to do a deep dive into the literature on the mental health of workers during pandemics.

Here's what I found. #thread

Seriously, so many laypress articles.

What evidence do we have on this, and further, what evidence do we have on strategies that mitigate these mental health issues in health care workers?

I presented these data the @UChicagoMed @UCCancerCenter grand rounds last week.

@UChicagoMed @UCCancerCenter But first, some definitions to set the stage:

Burnout, initially described by Dr. Maslach as the prolonged physical and psychological exhaustion related to a person's work. Not specific to medicine, although the definition has been honed for medicine (see slide). #burnout

Read 44 tweets
Let's talk about #COVID19 publications & #covardisation of the research. I have been following the literature last ~ 2 months & reviewed papers. I have a bit to say about it

Let's start first with 2 papers that came out today on #COVID19 and scholarly communication
---> Thread
First paper examines citations record, altmetric, social media... on early #COVID19 papers.
Out of 442 papers, only 26% primary studies => 21% -> basic science (too few) , rest clinical (case reports 42%)
Larger social media impact => high citations…
The 2nd paper examines wether #COVID19 has speed up #peerreview process
Answer is yes & peer review length has decreased by 1/2 due to reduce time for review
However trade off is publication quality is lower (e.g NEJM or CELL..)
This brings me to my point…
Read 13 tweets
【百万吨级核弹6连爆!王73的另一个仔:巨无霸金隅集团】1在2019年扬名全世界,不是因为它们有多么辉煌的业绩,而在2019年8月20日,金隅集团以51.87亿元人民币通过“竞拍”夺得市场价约500亿人民币的盘古大观“龙首”,也就是盘古大观的5号楼!红框示 Image
2 盘古大观“龙首”,是一栋44层建筑面积13.93万平方米的超5A写字楼。51.87亿是什么概念呢?也就是等于每平方米价格仅37236元日人币!!!而在安居客上面,盘古大观的价格是多少呢?来看看!138248元/平方米!咦?!那个每平米的10万元哪里去了??!! Image
Read 94 tweets

冒頭、Vol.2の #学校英語 の話を締めくくるために少し話を戻しますが、「#Phonics」(#フォニックス)というものを聞いたことがあるでしょうか。

#ネイティブ#英語話者 が、英語の #綴り#発音 の規則を学ぶために体系化された #学習法 です。
私たちが初見の #日本語 を読めるのは、文字が体系的だからです。

英語の綴り字も例外こそあれ #体系的 に作られています。

中学生レベルの知能をもってすれば、体系的に英語の綴り字とその規則を学ぶことで、#非ネイティブ の私たちでも初見の英単語のほとんどを正確に発音できるようになります。

#グローバル化 の進展の中で、#国際共通言語 である英語力の向上は #日本の将来 にとって極めて重要である」と #文部科学省#指針 も出ています。

(グラフは #中学生 対象の調査)
Read 28 tweets
THREAD from the new #bradykinin research (pre-print) from 🇳🇱:

"We propose that the severity of the disease and many deaths are due to a local vascular problem due to activation of B1 receptors on #endothelial cells in the lungs."

#COVID19 #kinins…
➡️"the B1 receptor on endothelial cells is upregulated by proinflammatory #cytokines

➡️ Without #ACE2 acting as a guardian to inactivate the ligands of B1, the lung environment is prone for local vascular leakage leading to #angioedema"


#bradykinin #COVID19
➡️"... and might explain the typical #CTscans and the feeling of people that they drown.

➡️In some pt., this is followed by a clinical worsening of disease around day 9 due to the formation antibodies directed against the spike (S)-antigen of #SARSCoV2 that binds to #ACE2"
Read 12 tweets
🚨2 years before the #CoronavirusPandemic, US officials visited #Wuhan's virology lab and warned DC that the lab’s work on bat coronaviruses and their potential human transmission represented a risk of a new #SARS-like #pandemic.😳

#COVID19 @ericgarland…
#China's research was supposedly designed to prevent the next #SARS-like #pandemic, but scientists question whether they took unnecessary risks (yes).

There is NO evidence the new #coronavirus was engineered, "but that is not the same as saying it didn’t come from the lab."🤬
The diplomatic cables sounded an alarm about the "grave safety concerns" at the #Wuhan lab, especially its dangerous work with bat coronaviruses.

The cables also suggest the possibility that the #pandemic could be the result of a lab accident (or leak) in #Wuhan.
Read 8 tweets
Si la lucha contra #COVID19Uruguay fuese un combate de boxeo a varios rounds, hoy Uruguay está recién en el primero. Hemos esquivado un par (solo un par) de cross y sin embargo hay una sensación de que la pelea está ganada.... NO. #QuedateEnCasa.
NADA cambió.
Por qué?
Al mes de iniciada la pandemia, Uruguay ronda los 500 casos. Pero es éste el número REAL de casos? NO. Claramente NO. Hay mucho más. Cuántos más? No sabemos. Todos los países tienen ese problema: el sub-registro. Por qué se ocurre? Hay varias razones, que no discutiremos ahora.
El hecho de que los casos graves en Uy no se hayan disparado puede ser una buena señal, si bien ellos son aproximadamente entre el 5-15% del total de casos. Es la punta del iceberg que podría ser reflejo de la masa total de hielo. Si es así, es muy bueno. Hay que confirmarlo.
Read 11 tweets

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