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Célestin BIGARRÉ Profile picture
Célestin BIGARRÉ
@CBigarre
Phd student at INRIA — Mathematical modeling and prediction of metastatic relapse — COMPO (COMPutational pharmacology and clinical Oncology)
Feb 27, 2023 • 10 tweets • 7 min read
Very excited to present my first article, "Mechanistic modeling of metastatic relapse in early-stage breast cancer (eBC) to investigate the biological impact of prognostic biomarkers" !
(supervision @SBenzekry)
#cancer #mathonco #mechanisticModeling #nlme

doi.org/10.1016/j.cmpb… Our model is (voluntarily) simple and describes the metastatic process through 2 mathematical parameters: alpha (growth) and mu (dissemination), to be confronted to distant metastasis-free survival (DMFS) data A unit-less simulation of the mechanistic model presenting t