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Carsten Peukert Profile picture
Carsten Peukert
@CarstenPeukert
👨🏼‍🎓Industry postdoc in #ChemicalBiology 🧪🧬🧫 anti-infectives, anti-cancer, sustainability & mentoring the next generation. 🐣356 ppm - private account.
May 4, 2023 • 13 tweets • 6 min read
#MyFirstChemSci 🙌🏼
Are you an antibiotic targeting RNA-P? You just got an upgrade! We used the microbial iron transport machinery to enhance potency and improve accumulation into bacteria, where cleavable linkers release.
tinyurl.com/3chw8pnt @ChemicalScience

A 🧵: (1|n) Image We found a way to enhance the potency of antibiotics targeting RNAP, rifamycins but also Corallopyronin A & Sorangicin A, by exploiting microbial iron transport to improve drug translocation across bacterial membranes using bacterial iron chelators- #siderophores. (2|n) Image