The @PATCHTrial, led by @RussellGruen, a study of pre-hospital TXA for severe trauma in adults at high risk of acute traumatic coagulopathy treated in advanced trauma systems, has been published today in @NEJM. #CCR23 Here’s a summary of what we did...
nejm.org/doi/full/10.10… ...& what we found (and a Poll to ask what you think).
@karimbrohi @HawkmoonHEMS @CritCareReviews @QldAmbulance @NSWAmbulance @AmbulanceVic @MedSTAR_SA @MazurStef @AmbVicMedic @ClinResearchNZ @HRCNewZealand @nhmrc @WgtnFree @StJohnNZ @VACAR_AV

The @TEAMtrialICU has now made it to the print edition of the @NEJM
nejm.org/doi/full/10.10…
Here are some reasons people have said our findings should be disregarded... Reason #1 to ignore the @TEAMtrialICU data:
"The patients were all deeply sedated."

Reality: Data as below. Deeply sedated is -3 or below & was pretty infrequent after day 1. In a heterogeneous population of sick patients, it is very difficult to do better than this.

The @TEAMtrialICU, led by ICU physiotherapy research legend @chodgsonANZICRC, has been published today in @NEJM
nejm.org/doi/full/10.10…
Here’s a summary of what we did & what I think the trial means. We enrolled 750 adult ICU patients receiving invasive mechanical ventilation and expected to remain ventilated beyond the calendar day after randomization who were sufficiently physiologically stable to make mobilization potentially possible.

I am pleased & proud to see the #PLUStrial published in @NEJM today. It is my 10th @NEJM paper! Here’s my list of @NEJM papers and what I think they mean for clinical practice #1: The #HEATtrial (Dec 2015) showed that using paracetamol to treat fever in ICU patients with suspected infections did not affect the number of ICU-free days. Mortality rates were similar in paracetamol & placebo-treated patients:
nejm.org/doi/full/10.10…

The @hrcNewZealand and @nhmrc funded #PLUStrial is the latest in a series of RCTs that have compared balanced crystalloids with saline in patients who are critically ill. It was published today in the @nejm nejm.org/doi/full/10.10… Millions of litres of intravenous fluids are administered around the world every day. For patients who are acutely ill, small differences in mortality attributable to fluid choice would have profound global public health importance

The #TTM2trial was published today in the @NEJM

Here’s a summary of what we did, what I think the trial means, and what next.
@ttm2trial @nielsen_niklas @CritCareReviews @NEJMnejm.org/doi/full/10.10… We enrolled 1900 adults with a coma after an out of hospital cardiac arrest with a presumed cardiac or unknown cause

Here’s what we did in the #PEPTICtrial, what we found, and what I think it all means. #CCR20 @jama_current We conducted an international, randomized, open-label, cluster crossover, registry-embedded trial to compare strategies of stress ulcer prophylaxis in mechanically ventilated adults implemented at the level of the ICU jamanetwork.com/journals/jama/…

The #ICUROXtrial has been published today in @NEJM. The 1st author (and our #ICUROXtrial project manager extraordinaire) is @dianemackle
nejm.org/doi/full/10.10… This #tweetorial is to highlight what we did, what we found, what I think is means, & what next.

Results of the #TARGETtrial, the largest critical care nutrition trial ever undertaken, are now online @NEJM
nejm.org/doi/full/10.10…
What we did, what we found, and what it means follows…
Please RT to help translate this new knowledge. Thanks to funding from @HRCNewZealand & @NHMRC we randomised 4000 participants from 46 Australian and New Zealand ICUs in less than a year and a half!