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Andre Kalil, MD MPH Profile picture
Andre Kalil, MD MPH
@DrAndreKalil
ID Doc, Transplant ID Director, Clinical Researcher and Trialist, ID/Critical Care Training, Epidemiologist/MPH, University of Nebraska Medical Center @UNMC_ID
Jan 20, 2022 • 9 tweets • 6 min read
#Remdesivir new trial just published

Here are the clinical implications:
Canadian trial (CATCO) in hospitalized patients with #COVID19 bit.ly/33uktIf
Compared to ACTT-1 trial bit.ly/3msi1In in patients on supplemental O2 as recommended by guidelines
🧵1/ ACTT-1 Highly Significant Mortality Reduction in Patients on Supplemental Oxygen:
bit.ly/3msi1In
2/
Jan 4, 2022 • 9 tweets • 2 min read
Should CDC recommend #COVID19 rapid antigen test for asymptomatic isolation exit?
R antigen test:
Picks up 2/100 who are contagious
Allows 3/100 to exit isolation still contagious
No help in 95/100
⬇️
Antigen test has no utility to exit asymptomatic isolation and may harm
⬇️
🧵1 FDA: Antigen test has a 60% false-negative rate in asymptomatic ppl at the infection start (screening)

Likely >60% at the infection end (isolation exit) → due to lower expected viral replication

But let’s use 60% assuming test will not lose performance at isolation exit
🧵2