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Caitlyn Vlasschaert Profile picture
Caitlyn Vlasschaert
@DrFlashHeart
Internal medicine resident and PhD student with @QMyPath. Nephrology, genetics, and molecular evolution. @NSMCinternship grad & current exec.
Reza Hosseini, MD MPH Profile picture Shanil Keshwani Profile picture 2 subscribed
Aug 13, 2020 • 9 tweets • 5 min read
“What is the role of vasopressin?”

A nephrologist will talk about osmolality and aquaporins.

An intensivist might talk about its use as a pressor.

But, ask an evolutionary or social scientist and you might be surprised by the answer…

#MedTwitter #NephTwitter #NSMC Arginine vasopressin (AVP), also known as antidiuretic hormone (ADH), is a short peptide hormone coded by ⒸⓎⒻⓆⓃⒸⓅⓇⒼ.

We have a similar peptide, ⒸⓎⒾⓆⓃⒸⓅⓁⒼ, floating around in our bodies.

Is this AVP, too?
Jun 28, 2020 • 9 tweets • 6 min read
Unlike most other animals, humans cannot convert uric acid into a more soluble compound.

Precipitated uric acid can cause a host of problems like gout and kidney stones.

What happened to our uricase?: a brief Tweetorial.

Fig. from pnas.org/content/111/10…

#NephJC #NephTwitter Uricase is many animals' golden knight: it protects against the Disease of Kings by converting urate to allantoin.

Great apes (including humans) do not have a functional uricase.

Why would this ever be an evolutionary favored trait, you ask?

Fig. from: jci.org/articles/view/…