#RheumatoidArthritis is triggered by immune responses to oral bacteria circulating in the blood in people with #GumDisease.

A thread to attempt to unpick this complicated but fascinating study from 2023👇👇👇

1/19
ncbi.nlm.nih.gov/pmc/articles/P… Oral bacteria frequently pass across our gum tissue and enters our bloodstream. This occurs to a greater extent in people with #gumdisease which makes the gums more leaky.
2/19

#PoorOralhealth / #OralDysbiosis / #GumDisease causes systemic diseases 101 ...

The bacterium Porphyromonas gingivalis causes #InsulinResitence (#Type2Diabetes)

A long thread to unpack this review paper
👇👇👇👇👇

1/25 frontiersin.org/articles/10.33…
The bacterium Porphyromonas gingivalis (#Pgingivalis/Pg) is the main causative agent of periodontitis (gum disease).
P.gingivalis is also directly implicated in the development of multiple important systemic diseases, including #Type2Diabetes.
2/25

Dear #MedTwitter
To help understand #LongCOVID I believe there are important lessons we first need to learn about the acute phase of #COVID-19. This is because (as I see it) they are different phases of the same disease.
#LongCovidAwarenessDay
A thread👇 The human body has 60,000 miles of blood vessels. The inner lining of these blood vessels – the endothelium – should be considered as an organ of the body. It is an organ which determines overall body physiological health.

Thanks to all who answered this quiz question.
Well done to those who noticed the question is ambiguous. It could mean...
Which pathogen-
-causes disease in the most people?
-has killed most people?
-is most lethal?

In answer to the first two, I think it’s this one👇
A thread …

https://twitter.com/DrGrahamLJ/status/1733153673214054458

Malaria, TB, Y.pestis have certainly killed many people.

Ebola has high lethality, but rabies wins this one.

In terms of which pathogen causes most disease AND killed most people, I now believe the answer is the oral microbiome bacteria - Porphyromonas gingivalis

Thanks for sharing this Robert. I share your concern regarding routine use of mouthwash.
Please can I pick apart this study a little because there are important points to make…
1/

https://twitter.com/robertlufkinmd/status/1730223842428060006

2/
Firstly, this is not an interventional study. It is an observational study. It acknowledges that causation cannot be inferred (which is good).
The study simply asked a population of overweight people if they used mouthwash. Then waited to see if they developed hypertension.

Please can I add a different view on the #COVIDinquiry, something which the inquiry will ignore.

#COVID-19 is a disease!

The COVID-19 pandemic is caused by COVID-19!

Pandemics and the diseases which cause them are not the same thing!

A thread ... Firstly, I have some sympathy for politicians (not those in question in the UK, but more generally) because politicians know about politics, economics, law etc., they do not know about biology.

Summary thread of the oral-vascular-pulmonary model of #COVID-19 lung disease, why this is important and what to do about it.

Also potentially relevant in #LongCOVID

@SpringerNature review -

1/21 bit.ly/3ME7LtC
2/21
Initial viral infection of epithelial lining of the upper respiratory tract mucosa (nose and mouth) ...

Use of a nasal spray makes sense when you know that the ACE2 receptor (cellular receptor for the #SARS2 virus) is expressed in the nose 200-700 times more intensely than in the airways of the lungs.
See this - erj.ersjournals.com/content/56/3/2…

https://twitter.com/Clean_Air_Club_/status/1685790242681331713

The mouth is also a site of initial infection early in the disease course of #COVID-19.
Multiple epithelial cell types in the mouth are susceptible to infection and viral replication.
nature.com/articles/s4159…

More on imaging in the context of #LongCOVID

A thread of summarising this key paper titled -

'Pulmonary circulation abnormalities in post-acute COVID-19 syndrome: dual-energy CT angiographic findings in 79 patients '


H/T M. Oudkerk (not on Twitter)doi.org/10.1007/s00330… Objectives of the study

'To evaluate the frequency and pattern of pulmonary vascular abnormalities in the year following COVID-19'

Thanks for playing the anatomy game everyone

https://twitter.com/DrGrahamLJ/status/1662989869323255808?s=20

Many mentioned the skin as 1 of their 5 organs

Some mentioned the gut (intestine/bowel)

There’s another organ that bridges the skin and gut, which nobody has mentioned …

Published 2 years ago...

The COVID-19 Pathway: A Proposed Oral-Vascular-Pulmonary Route Of SARS-CoV-2 Infection And The Importance Of Oral Healthcare Measures
bit.ly/36uEwar

What has changed since then?
Please see this thread ... The world has caught up and #COVID-19 is now widely understood to be a vascular disease. This includes the severe acute lung disease which itself is not a respiratory 'pneumonia' but a 'vasculopathy'

See this explanation of the imaging (Nov 2020)

Important news about XXB1.5 pointing out that infection is more via the ACE2 receptor than previous Omicron variants.
But … the mouth is not mentioned as an important site of infection…. cambridgeindependent.co.uk/news/fast-spre…
A thread … 1/ 2/ Minor salivary glands over the surface of the tongue, inner surface of the lips, the fauces and soft palate are highly susceptible to infection and replication. Epithelial cells in these areas express the ACE2 receptor.
nature.com/articles/s4159…

Based on imaging of the lung disease post acute #COVID/#longCOVID there might be 2 things going on

1- fibrosis due to the acute phase lung injury
2 - endothelial damage - not related to the acute disease

The literature doesn't yet reflect the complexity but getting there ... In those with respiratory symptoms at 3 months - on Dual Energy CT scans
- 5% have visible clots in lung arteries
- 65% have microangiopathy (disease of small blood vessels of the lungs)

ncbi.nlm.nih.gov/pmc/articles/P…

1/
A thread to explain the reasons why it is important to care for the mouth if you have #COVID.

If you don't have time to read is all, here is the mouth care guidance (patient information sheet) we are providing our patients @SalisburyNHS ...

salisbury.nhs.uk/coronavirus/co…
2/
... and this is a presentation giving more detail.

Highlights in thread below.