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Mark Ong Profile picture
Mark Ong
@DrMarkOng
Consultant Histopathologist based in England, UK. T and RT not medical advice. Opinions my own. Nisi dominus frustra.
Jul 14, 2020 • 5 tweets • 7 min read
How best to classify this gastric tumour? #GIpath

>95% of tumour is a WD NET (like picture 1), <5% shows mucin & goblet cells (pictures 2-4). Complicated by neoadjuvant chemotherapy for adenocarcinoma (presumably index biopsies looked more epithelial). IHC next tweet... Synaptophysin -ve in epithelial component. Chromogranin strong +ve in NE component, weak in epithelial component. Ki67 high in epithelial component, low in NE component.

Are the mucin-producing areas amphicrine (dual differentiation in 1 cell) or a separate epithelial component?
Feb 25, 2019 • 6 tweets • 5 min read
30♀️ posterior chest wall mass. Good example of this entity. IHC in next tweet. #dermpath #pathology #IHCpath: CD4 is also a myelomonocytic marker, so weak staining is expected in macrophages. Only strong CD4 positivity is counted as genuine for T-cells.