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Eddie Cliff Profile picture
Eddie Cliff
@Eddie_Cliff
haematology registrar | @harvardmed fellow @PORTAL_research | evidence-based medicine & policy | lymphoma | myeloma | Fulbright | writer | host @BloodCancerTalk
May 16, 2023 • 8 tweets • 8 min read
Fantastic heme grand rounds on HLH at @DanaFarber @BrighamHeme today from @ZorefAdi @CCHMCPostdoc - a 🧵

Starting with a timeline, the pathogenesis and defining the clinical syndrome of HLH
#HLH #lymsm (1/8) ImageImageImageImage How to diagnose HLH? Soluble CD25 and ferritin are the most specific inflammatory markers (best ROC), so @ZorefAdi et al combined them into an 'optimised HLH inflammatory' (OHI) index, with an improved specificity for HLH

ashpublications.org/blood/article/… @BloodJournal (2/8) ImageImage
Jan 31, 2023 • 8 tweets • 4 min read
Bispecific antibodies, infections & myeloma: a 🧵

Myeloma patients are at high risk of infections

An antibody that drags T-cells to attack plasma cells probably impacts immunity - but we don't know for sure yet

ascopubs.org/doi/full/10.12… @JCO_ASCO @ManniMD1 @akesselheim
#mmsm We compiled infection rates across myeloma bispecific trials, updated to include #ASH22 data

The majority of patients across trials developed infections, w 20-45% developing grade 3 infections & some deaths from infection ⬇️

Note the frequency of neutropenia & hypogam