Share this page!

Enter URL or ID to Unroll

You can paste full URL like: https://x.com/threadreaderapp/status/1644127596119195649
or just the ID like: 1644127596119195649

How to get URL link on X (Twitter) App

  1. On the Twitter thread, click on or icon on the bottom
  2. Click again on or Share Via icon
  3. Click on Copy Link to Tweet
  4. Paste it above and click "Unroll Thread"!
  5. More info at Twitter Help
Luciano J Costa Profile picture
Luciano J Costa
@End_myeloma
Mary and Bill Battle Professor of Multiple Myeloma. Immunotherapy , cellular therapy, clinical trials. I unapologetically believe MM can be CURED.
Jun 16, 2024 • 10 tweets • 2 min read
Some considerations on long-term follow-up of the CASSIOPEIA randomised controlled phase 3 trial - The Lancet Oncology 1/x thelancet.com/journals/lanon… 1st things 1st: Celebrate! It is not everyday that a drug changes OS in NDMM, particularly for the young TE patients. It only happened once for Len (in CALGB maintenance trial) and once for Bortezomib ( GIMEMA-MMY-3006, 15 years after Bort availability). 2/X Image
Nov 15, 2023 • 10 tweets • 3 min read
#ASH23 #myeloma Abstracts I find most clinically relevant, no particular order @mtmdphd 1/x Dara-Vd in t(11;14) RRMM @NBahlis Very impressive efficacy. Kudos for reporting MRD by ITT in a single arm trial. 2/x
ash.confex.com/ash/2023/webpr…
Oct 1, 2023 • 7 tweets • 2 min read
@Rfonsi1 , brilliant and-depth analysis as always 🙏🏼🙏🏼. I would also highlight CANOVA is a textbook example of informative censoring and its dangers. Censoring should be small, balanced between the arms and not "informed" by trial design. Let's see what happens here 1/X Large number of censoring in the Pd arm. These are folks that are not dropping off for progression or toxicity, but for other reasons such as MD or patient choice. Consequences? It eats away power (fewer patients left) and arms can no longer be assumed similar 2/X Image
Sep 28, 2023 • 16 tweets • 3 min read
MASTER trial final results out in @TheLancetHaem Thanks @bdermanmd for the very nice commentary! Of course I find the results COOL! But I find the story behind it is just as nice! 1/X
sciencedirect.com/science/articl… c2015, moAbs cooking, MRD by NGS gaining steam, I had time, and had very supportive friends/collaborators @Phari @nsc_natalie @myeloma_doc_com @Chhabra_mayo @ravivij . Let's try something bold? Very naive, in retrospect. Glad my friends didn't mind 2/X
Apr 5, 2022 • 25 tweets • 48 min read
@jmikhaelmd @BonumCe @JanssenUS @pfizer 2/ 🎇🆓 AMA PRA Credit 🎇
CME ℹ️ & ref list👉 bit.ly/3DtOjtZ
🗝️ Disclosure info 👇
#BonumCE #MMSM Image @jmikhaelmd @BonumCe @JanssenUS @pfizer 3/🛫Taking off...
🤔#biomarker definitions
🎯Dx biomarkers distinguish👥w disease &👥 w/o
🔮Prognostic biomarkers forecast likelihood of a clin event, dz progression or recurrence
🔮Predictive biomarkers identify 👥 more likely to experience favorable/unfavorable effect from 💊💉 Image