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Evan Weber Profile picture
Evan Weber
@EvanWeberPhD
Assistant Professor @PennMedicine @ChildrensPhila | Bridge Fellow @parkerici | CAR-T cells, immunotherapy, epigenomics, T cell exhaustion | he/him
Apr 1, 2021 • 15 tweets • 10 min read
I am thrilled to share our new paper out in @ScienceMagazine! We show that transient disruption of CAR signaling, or "rest", can reinvigorate exhausted CAR-T cells and boost anti-tumor functionality #CART #immunotherapy #IO

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doi.org/10.1126/scienc… This project began with a simple question: if persistent CAR signaling alone can promote exhaustion, what happens if you turn the CAR off? To test this, we first teamed up with Tom Wandless to create a drug-regulatable CAR system (DD-CAR) that enabled tunable CAR expression
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