Gioele La Manno Profile picture
Professor at @EPFL - Neurodevelopmental systems biology lab. Analysing single-cell data since the early days. Biologist loving math and computers.
Feb 24, 2021 10 tweets 6 min read
Did you know #lipids control cell identity? Yes, they do! Happy to share our first preprint on #singlecell #lipidomics in collaboration with @gio_dangelo and a fabulous team led by @CapolupoLaura and Irina Khven. biorxiv.org/content/10.110… Image We used #MALDI imaging mass spectrometry to measure the single-cell lipidomes of hundreds of individual human dermal #fibroblasts. We identify specific lipid metabolic pathways that display cell-to-cell variability. Unexpectedly, single cells clustered by lipid composition! Image
Aug 5, 2020 7 tweets 5 min read
Excited to release the first preprint from my lab: a new framework to convert existing NGS tube-reactions into spatial techniques using compressed sensing principles and a probabilistic algorithm that we call #Tomographer biorxiv.org/cgi/content/sh… In the lab we are thrilled about possibilities offered by #spatialomics methods, and a bit impatient... it will take a bit until methods for the different omics are available. That's when we had the idea of using already available low-input protocols to obtain spatial information