Geriatrician, scientist, Radboudumc, Alzheimer,Hypertension-Brainbloodflow, Donders Institute. Author ‘Wat kun je doen aan dementie?’
Dec 6, 2021 • 7 tweets • 2 min read
1/7 Great to see the enthusiastic responses to my #autoregulation tweets. This is what keeps Twitter great and now I know I'm not the only #autoregulation#nerd. A few more tweets about autoregulation and CBF as a follow-up:
2/7 When you think about autoregulation and cerebral blood flow (CBF), keep in mind that, even if autoregulation works normally, or blood pressure (BP) is stable, there are other things that can and will affect CBF:
Dec 4, 2021 • 10 tweets • 4 min read
Time for a #factcheck on cerebral autoregulation.
1/10
"Cerebral autoregulation is the mechanism that keeps cerebral blood flow (CBF) stable across a wide range of perfusion pressure".
WRONG. But widespread... This is only true for very slow changes in blood pressure (BP).
2/10 For faster changes in BP, CBF changes almost as much as BP. E.g. the 10-20% drop in BP when we stand up leads to a 10-20% drop in CBF. Autoregulation can not prevent this drop, it only makes sure CBF recovers before BP does.
