Here again are my #Top10 Infectious Diseases papers of 2022. Not in order (alphabetical by first author). Non-COVID (because >120,000 COVID papers in 2022). Have to be at least one of: Paradigm Shifting, Practice Changing or Dogma Challenging #IDtwitter 🧵
1. Cheetah Trial, Lancet Vol 400, Nov 2022
Cluster RCT, 81 hospitals and 13,301 pts having surgery. Compared with usual care, routine change of gloves and instruments before wound closure reduced the 30-day SSI incidence from 18.9% to 16.0% (adjRR 0.87 [0.79-0.95], p=0.003)
Oct 25, 2022 • 10 tweets • 2 min read
On Acute General Medicine service (#internalmedicine) at the moment, and realise I repeat myself a lot when telling the junior doctors (interns, residents, fellows/registrars) how we should do things. Also applies to #IDTwitter I think. Here are a few of them (in a thread) 🧵
1. Don't look at the radiology reports before you've looked at the X-rays/scans yourself, and decided what you think they show. Otherwise you'll never get good at interpreting them. (exception: ultrasounds!)
Oct 18, 2020 • 4 tweets • 1 min read
My thoughts on #SOLIDARITY results thus far
Strengths:
Huge size, high power n=11,266
Objective endpoint
Highly generalisable (405 hospitals, 30 countries, all 6 WHO regions).
Groups well matched.
High compliance with protocol.
Not sponsored by company with a material interest
Limitations 1:
Eligibility criteria – unknown duration of symptoms pre-rando
1ry endpoint – Listed as *in-hospital* mortality, but all analyses use *estimated 28-day mortality*
Subgroups crude but pragmatic (ventilated or not). Ironically, did not use WHO ordinal scale!
