Clinically, it's been well observed that children with disruptions to their microbiota during infancy (<1year old) have an increased risk for allergies. This has been widely reported and connected to the developing microbiota at this time. (A thread) A good portion of the later half of my postdoc @newberrylab was focused on mechanisms regulating exposure of the immune system to the microbiota prior to weaning, which we applied to #allergies , and I'll summarize here.