Lance Turtle Profile picture
Consultant in infectious diseases @LivHospitals, reader in infectious diseases @LivUni_IVES. I work on immunology/viral pathogenesis.
Feb 1, 2023 12 tweets 4 min read
New publication!

Just published today, is our latest analysis of the effects of COVID-19 on people with compromised immune systems.

journals.plos.org/plosmedicine/a…

A 🧵. 1/10 This study used the @ISARIC1 @CCPUKstudy dataset, where we were able to analyse more than 150,000 people in the UK, who were admitted to hospital during the first two years of the pandemic.
2/
Dec 8, 2021 5 tweets 2 min read
Data are emerging now that #omicron is much less sensitive to neutralising antibody induced by vaccines that other SARS-CoV-2 variants. But this is not the same as vaccine effectiveness - this remains to be seen.

Here is an example: 1/5 These are data from the Screaton lab - delta neutralising titres are about 6 fold lower for AZ than Pfizer. 2/5
Mar 26, 2021 21 tweets 11 min read
Our paper on immune responses to COVID vaccine (mostly Pfizer) in 237 healthcare workers, 124 #SARSCoV2 naïve and 113 previously infected, from the PITCH consortium @pitchstudy is out as a pre-print today.
papers.ssrn.com/sol3/papers.cf…
@pitchstudy
@DHSCgovuk
@UKCICstudy
@PHE_uk
1/16 We already know from the @PHE_uk #SIRENstudy that Pfizer vaccine is protective in healthcare workers. In this paper, we investigate possible mechanisms of protection. 2/17