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Leslie Crews Profile picture
Leslie Crews
@LeslieCrewsPhD
Assistant Professor in the Division of Regenerative Medicine at UC San Diego (opinions are my own), stem cell biologist, myeloma researcher, and travel addict.
Jan 20, 2021 • 15 tweets • 18 min read
Our first paper authors.elsevier.com/a/1cRqD6tu0Cbo… is now out @CellStemCell! With @ionispharma & the Jamieson Lab @UCSanDiegoDRM, we found that selective #antisense oligonucleotides inhibiting #IRF4 reduce disease burden & #multiplemyeloma #regeneration in #cancer models. @CellPressNews 1/ Image IRF4 (interferon regulatory factor 4) is a key plasma cell transcription factor that is known to play a critical role in #myeloma progression. It's been shown to activate networks of #cellcycle and cancer regulators, including the notorious #cancer and #stemcell gene, #MYC. 2/ Image