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Munir Pirmohamed Profile picture
Munir Pirmohamed
@MPUoL
David Weatherall Chair of Medicine (UoL) and NHS Chair of Pharmacogenetics. Research: drug safety, pharmacogenomics and personalised medicine. Views my own.
Feb 3, 2023 • 7 tweets • 11 min read
A journey which started in 2016 has led to the publication of the #PREPARE study in @TheLancet today. In this #randomised study, we show that a 12-gene panel can reduce #adverse_effects by 30%. authors.elsevier.com/c/1gX95V-4XHGbk @CDSS_Liverpool @pandtuol A 30% reduction in adverse reactions from a single #intervention is remarkable. news.liverpool.ac.uk/2023/02/03/mat… #pharmacogenetics #personalisedmedicine #adverse_effects. The study was funded by the Horizon 2020 program by the @eu_comission
Feb 2, 2023 • 5 tweets • 9 min read
Great to see my #review on #pharmacogenomics in @NatureRevGenet. rdcu.be/c4iur
@BritPharmSoc @LivUni @pandtuol @CDSS_Liverpool @pgrnhub @pharmgkb @nwgmsa @LivUniISMIB
Key messages: A. Wider definition of #pharmacogenomics
B. Pharmacogenomic #variation is common, we are exposed to many #drugs which require pharmacogenomic #guidance
C. There is increasing #evidence of #clinical #utility of #PGx