For the AJ Leonardi fans recent quote posts of me (he blocked me, so it took others to point them out🙏; I've returned the favour now), I'll add that the definition of "immune" or "immunity" does not imply never getting infected. It's a term scientists use & it can differ from.. ..that used by you in the wider community.
To us, if I can speak for all scientists (!I can't🙂), it means your body has mounted an immune *response*. That response - such as the one _most humans_ mount to SARS-CoV-2 after infection (whole virus) or vaccination (mainly Spike...

#COVID19 in Australian hospitals over the last 12 months.
Creeping up from the lowest base over that period.
But what is the State of Queensland doing? I don't think anywhere else in Aus has had this strange little peak and drop at this time.

😷Respiratory virus data in these tweets are from Sullivan Nicolaides Pathology (SNP) lab weekly report.
😷They service #Queensland, northern New South Wales and wider Darwin area and Alice Springs
•Reports: snp.com.au/clinicians/res…
•SNP locations:snp.com.au/our-locations/ 😷A reminder that whatever respiratory signs & symptoms bring a patient in for a test/Doctor's visit - many very different respiratory viruses can cause that disease. Only a good pathology laboratory test has a hope of identifying a cause.

Equatorial Guinea quarantines 200 after unknown hemorrhagic fever deaths.
reuters.com/world/africa/c… "Equatorial Guinea said on Wednesday that it had registered the "unusual epidemiological situation" over the past weeks in Kie-Ntem province's Nsok Nsomo district that caused nine deaths in two adjacent communities over a short period."

🔅What follows is not to minimise serious impact of COVID-19. Because many things are true at once. 🔅

Pre-pandemic, excess deaths from heart & other issues were associated with respiratory virus seasons-Flu, RSV, MPV etc.
Cleaned air & 😷 will also reduce risk of those harms We've never succeeded in removing those harms or, in many nations, made serious non-vax efforts to reduce the risks, although a well matched flu vaccine likely helps them for flu.
But now SARS-CoV-2 has added more harms to the pile.

We are all playing Covid roulette. Without clean air, the next infection could permanently disable you.
-a pretty full summary of the worst of it all.
1/7
theguardian.com/commentisfree/… "Do we really mean to sit and watch as this infection encroaches on our freedom to be well, brutal winter after brutal winter?"
🦠Of course "No", but I can't square that with the fact that in my lifetime, there's been no action but a vaccine for the same question about influenza

Hey didja hear the buzz about the latest recombinant MPV variants reported from China?

No. You probably didn't. And why would you have?

We mostly ignore that stuff & the contribution this & other viruses continually make to our death, harm & hospitalisation baselines. And while an arbitrary human naming system says all variations are called 'MPV' (human metapneumovirus; not current name btw), there are in fact distinct lineages & variants & constant evolution & recombination.
The Chinese study is just one I recently saw, of many out there.

Study on Measles Transmission in China Has Implications for Controlling Epidemic Worldwide shar.es/aflJn9 via @Columbiamsph of the slice of time over which diseaseX is being observed. Let's use China & measles as an example.
journals.plos.org/ploscompbiol/a…
🔴"we found that large industrial cities in China with large migrant populations supported 𝗲𝗻𝗱𝗲𝗺𝗶𝗰 measles transmission during 2005–2014"
2/x

Frikkin astounds and annoys me that we continue to focus only on the hyper detailed genetic variation of SARS-CoV-2, yet give none of that prime time attention to Flu virus or RSV, MPV & others driving hospitalisations around the world. Where's the genotyping & narration? We should have the capacity to do this, at a wider range of sites than prepandemic times. We have vaccines for some of these (now or soon). We have a more knowledgeable populace. Shouldn't we be *building* on genomics, not slipping back to a pre-genomic communication age?

🧀Version 5.3 of my adaptation of a Swiss cheese transmission risk reduction graphic; applied to 𝙖𝙣𝙮 airborne virus
🧀Background and version history of the image up to this version, now updated on my blog:
virologydownunder.com/the-swiss-chee… 🐁Added slices, reduced some words
🐁Added misinfo mice-because, the world
🐁Change shared responsibilities to Government/Corporate because better bang for buck if 𝒕𝒉𝒆𝒚 clean air in shared spaces
🐁Removed the person's mask

Comparison of Rhinovirus A–, B–, and C–Associated
Respiratory Tract Illness Severity Based on the
5′-Untranslated Region Among Children Younger
Than 5 Years.
academic.oup.com/ofid/article/9… Among 713 children with an acute respiratory illness under 5 years of age who did not test positive for another (coinfecting) virus, the severity of illness was investigated for those who tested positive for one (of many) rhinoviruses (RVs).

This is the part we need a better future plan for: counteracting - or forging ahead - in the face of predictable "pandemic fatigue".
Arguably a time of fatigue is always the riskiest time for huge & ill conceived missteps.

https://twitter.com/MackayIM/status/1566196988475219968

Planners could clearly see before we opened up that we'd get lots of cases. Models had shown this as well.
We couldn't prevent that.
We could however have prepared much better. But we rushed to cross the "opening up" line.

I'm looking forward to seeing the first Ep tonight. I only have expectations of it being visually beautiful. I'm hopeful it will craft an interesting tale with all new characters to love, and episodes to watch every Xmas for the next 20+ years!😁
#NoPressure #RingsOfPower

https://twitter.com/MackayIM/status/1565944391965249536

First Ep down.
Really really enjoyed. The teens weren't happy with some of the mullets & one character's casting (how can they turn into the older version?) also a non kingly looking king & modern haircut also bugged them- didn't bother me.
@WetaWorkshop killed it as usual❤️

#Flu in #Queensland, week to 28AUG2022
😷Total numbers are low but a little tail is wagging 😷Hospital admission numbers because of #flu, broken up by region of Qld, with historical context.
🤒Few but lingering at that level

"The mutations [SARS-CoV-2] just keep on coming"
They do. And they will. Unless the world undertakes the kind of global program used to eradicate polio.
And let's be real. We're just not going to be doing that. Nope.
So what does that mean? It means the virus will keep evolving in whatever direction results in a successfully transmissible new variant. You may have heard all this two years ago. RNA viruses like this one continually evolve. Nothing has changed since then except much more immunity to try to escape.

Optimizing and Unifying Infection Control Precautions for Respiratory Viral Infections
-I love this piece to absolute bits. academic.oup.com/jid/article/22… "is high time to modify infection control guidelines for respiratory viruses to recognize that that their transmission is more alike than different and that most transmission is attributable to aerosol inhalation"

‘Not some weird elitist class’: the scientists bringing an urgent message to the streets of Hobart
-makes some really good points.
theguardian.com/science/2022/a… I like this one especially...
“It really bothers me how exclusionary science can be. You’ll have a university that brings, every week, some interesting researcher to give a talk to some departmental seminar for 30 people. And the public is not invited."

😷Australian National #Flu data up to 31JUL22.
🦠lab-confirmed total cases⬇ (peaked in ~first week of June)
Graphs from: www1.health.gov.au/internet/main/… 😷Yes, there is undoubtedly more testing capacity in Aus after labs beefed up PCR testing for the pandemic.
😷To check if this is a real change in #flu cases, we can look at positivity rate, deaths, hospital beds & ICU occupied beds with flu-positive patients

A 𝙢𝙖𝙨𝙨𝙞𝙫𝙚𝙡𝙮 important thing still missing from conversations we're not having: excess death in winter-now & pre-pandemic.
•Respiratory viruses play a role in such seasonal death & harm
•In big flu years-like 2017 & 2019-we saw excess deaths In low #flu years like 2018 & in 2020-21 (when we briefly cared about protecting each other & our older populations from a pandemic pathogen), we saw a real drop in deaths in accordance with the huge effort we put in to prevent virus transmission & protect our healthcare system.

I'm not going to this year's Qld #Ekka but I am going to make scones.
And hot dogs.
And have strawberries & cream ice cream for desert tonight. And eat small chocolates. They came out okay.

We know masks/respirators mechanistically filter our particles–effectiveness varying with type, style, fit and use.

•They work in practice, not only in theory.

But that doesn't mean they work all the time. The use of 'masks' (overarching term) 𝗰𝗮𝗻 reduce the risk of transmitting an airborne pathogen.
They are imperfect. They are not a panacea. They cannot be used alone. They are a leaky\"holey layer". This means that outbreaks & epidemics still progress.