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Mat Legut, PhD Profile picture
Mat Legut, PhD
@MatLegut
Unconventional T cell biologist and genome engineer. Previously @cardiffuni @nyuniversity @nygenome 🏳️‍🌈
Mar 16, 2022 • 30 tweets • 20 min read
Really chuffed to share our latest work from Sanjana Lab out in @nature today (nature.com/articles/s4158…).

We tested >12,000 genes to find positive regulators of T cell proliferation to be used for next-gen #immunotherapies.

A thread... (2/28) T cell therapies have shown the potential to cure patients from #cancer – but even in B cell cancers, relapses outnumber cures… One of the problems is limited T cell persistence. #celltherapy #CARTcell