BMT & Cellular Therapy | Secretary @ASTCT | Co-Chair @ASTCT CoPG | #bmtsm #CARTcell #lymsm | Personal views | Physician not Provider | 🇵🇰 🏏 🇺🇸 🏈
May 12, 2021 • 10 tweets • 5 min read
Key takeaways from LOTIS-2 study leading to Loncastuximab approval in R/R DLBCL # Tweetorial #lymsm@ccarlostella@paolocaimiMD
Open-label; single arm; Single agent (important for efficacy data)
No exclusion for pri refrac; double hit NOT excluded (1/10) thelancet.com/journals/lanon…
LOTIS-2 dosing of 150 µg/kg every 3 weeks (Q3W) for 2 doses followed by 75 µg/kg Q3W deduced from large phase 1 study in @BloodJournal (2/10) pubmed.ncbi.nlm.nih.gov/33211842/
