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Mehboob Kalani Profile picture
Mehboob Kalani
@MehboobKalaniMD
MD |PCCM Fellow | Former Chief | Opinions ≠ Medical Advice | #EBMfanatic #Barcaforlife #TheNorth
Apr 15, 2019 • 7 tweets • 5 min read
nejm.org/doi/full/10.10… #LastWeekOnNEJM We reviewed the ANNEXA-4 Trial @AHNtoday for #AHNIMRes This trial was conducted to show the effectiveness of Andexanet Alfa as a reversal agent for major bleeds caused by Factor Xa inhibitors @TKapetanos @NEJM @KaminskiMed @Rick_Pescatore Andexanet alfa is a modified inactive form of human factor Xa designed to bind and sequester factor Xa inhibitor molecules, thereby rapidly reducing anti-factor Xa molecules and activity