Primary cilia as dynamic and diverse signalling hubs in development and disease go.nature.com/3GXbr6T #Review by @Mill_lab, @t_soren & @LottePedersen12 Primary cilia are essential for regulating signalling pathways during development and adult homeostasis. Mutations in genes affecting primary cilia cause an overlapping spectrum of >30 human diseases and syndromes, the ciliopathies.

Human-specific genetics: new tools to explore the molecular and cellular basis of human evolution go.nature.com/3JLDI2I #Review by @Lab_Pollen, @KlkUmut, Craig B. Lowe & @GrayCampLab
@UCSF @UniBasel_en @DukeU In this Review, the authors discuss our latest understanding of evolutionary genetic changes that are specific to humans, which might endow uniquely human traits and capabilities

Lineage tracing meets single-cell omics: opportunities and challenges go.nature.com/2UPu2cl Our 2020 #Review by @danwagnerlab and @KleinLabHMS
@harvardmed @UCSF A fundamental goal of developmental and stem cell biology is to map the developmental history (ontogeny) of differentiated cell types

Organization and expression of the mammalian mitochondrial genome go.nature.com/3MqLEV0 #Review by @TheRackhamLab & @FilipovskaLab The mitochondrial genome is co-localized with DNA replication machinery, which maintains and propagates it in cells, and gene expression machinery, which synthesizes essential mtDNA-encoded components of the respiratory chain required for energy conversion

From systems to structure — using genetic data to model protein structures go.nature.com/3ncLCWC #Review by @HannesBraberg, @ig_ech, @rmkaake, @salilab_ucsf & @KroganLab
@UCSF @GladstoneInst @QBI_UCSF Recent technologies use large-scale genetic and evolutionary datasets to model the structures of proteins and their complexes

Measuring and interpreting transposable element expression go.nature.com/3epDxrb #Review by @sophie_lanciano and @retrogenomics @ircaninstitute @uca_research @inserm @INSB_CNRS Computational tools to analyse RNA-seq data often discard reads derived from transposable elements (TE) but measuring TE expression helps to understand when and where TE mobilization occurs and how it alters gene expression, chromatin accessibility or cellular signalling pathways

#Free for 1 month: Towards a comprehensive catalogue of validated and target-linked human enhancers go.nature.com/2O6ezSC #Review by @MollyGasp, Jacob Tome & @JShendure This Review discusses the evolving definitions of transcriptional enhancers and the modern experimental tools to identify, characterize and validate them.