Othman Al-Sawaf Profile picture
Physician-scientist, Haematology & Medical Oncology. @UniCologne Visiting Scientist @TheCrick @uclcancer @SwantonLab
Oct 28, 2021 10 tweets 5 min read
Delighted to share our latest paper in #JCO, in which we suggest an MRD growth model of CLL, including new data from the CLL14 study (Ven-Obi vs Clb-Obi). #leusm #GCLLSG @ASCO_pubs

bit.ly/2ZyAVEZ

Some results in a quick 🧵 1/n 1.) We used NGS-based MRD quantification of >2,000 PB samples to devise a non-linear mixed effects model for outlining MRD growth after tx. There was wide heterogeneity in MRD growth trajectories that was dependent on various clinical, serological and genetic characteristics.