physician-researcher, paediatrician, ME/CFS since 2016. This account is about ME/CFS (may also visit: @kinderverstehen: on child development (German)
Jan 10 • 7 tweets • 2 min read
1/7 In this study, a lot can be learned about the potential role of the endothelium in the pathobiological matrix of #MECFS:
A critique that I have is that the most central question in any #MECFS hypothesis ....nature.com/articles/s4141…2/7 ... is touched from a narrow angle only (here: with reference to the muscles only).
Now what is the most central question of any #MECFS hypothesis?
It is: How does this hypothesis explain #PEM? After all, PEM is what defines #MECFS.
May I make a few suggestions?
May 9, 2022 • 13 tweets • 3 min read
1/13
A 🧵on our work on the role of #glia in #MECFS frontiersin.org/articles/10.33…
Our paper explains why ME/CFS research may benefit from a closer look at the role of the immune system of the brain.
2/13
Many things are known about the pathobiology of ME/CFS. There is evidence for (e.g.):
- immune dysfx
- metabolic / mitochondrial / peroxisomal dysfx
- endothelial / vascular dysfx
- dysfunction of the autonomous nervous system
and the CNS in general
