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Alex Wyatt Profile picture
Alex Wyatt
@ResearchWyatt
Prostate cancer genomics and ctDNA. Assistant Prof for a precision oncology team @VanProstateCtr @UBCmedicine
Jul 20, 2022 • 7 tweets • 4 min read
Here’s our @Nature paper on v deep whole-genome sequencing of serial ctDNA and met tissue. @cherberts1, Matti, Joonatan et al applied new methods to give fascinating insight into temporal #ProstateCancer clonal complexity and evolution of resistance. 1/7 nature.com/articles/s4158… Image ctDNA is a composite of distinct cancer populations, with small contributions to total ctDNA from each metastasis. Intra-patient clones are typically similar but can exhibit startling differences in key features such as whole-genome doubling status or mutational signatures. 2/7 ImageImage