Mom, Wife, Onco-nephrologist. Founder and Co-president of American Society of Onco-Nephrology. Co-PI of STOP-COVID. Exercise and wine enthusiast
Dec 8, 2021 • 10 tweets • 6 min read
Do cyclin-dependent kinase (CDK) 4/6 inhibitors cause acute kidney injury (AKI)? #onconephrology#Thread
A little #tweetorial about CDK 4/6 inhibitor-associated AKI: what we know already, and what we found kireports.org/article/S2468-…
3 CDK 4/6 inhibitors (palbociclib, ribociclib, and abemaciclib)have been approved for HER2-negative metastatic breast cancers. CDK 4/6 inhibitors help overcome resistance to endocrine therapies by preventing cell-cycle progression and cancer growth (frontiersin.org/articles/10.33…).
Oct 8, 2021 • 11 tweets • 7 min read
*NEW ARTICLE*
What does a nephrologist need to know about immune checkpoint inhibitor-associated AKI (ICPi-AKI)?@DavidLeaf9#Thread
my first #tweetorial with help from @kdjhaveri jitc.bmj.com/content/9/10/e… (1/11)
Why does it matter? ICPi-AKI can lead to:
*Discontinuation of ICPi therapy
*Irreversible loss of kidney function
*Prolonged courses of immunosuppression (2/11)
