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Twitter for TAG's Basic Science, Vaccines & Cure Project, by Richard Jefferys. Primary Treatment Action Group twitter is @TAGTeam_Tweets
6 Apr
Unfortunately there's misinformation circulating about this #HIV vaccine study. It's not mRNA but protein, and there's no expectation of efficacy - it's a possible first step on a long road toward persuading B cells to make protective antibodies scripps.edu/news-and-event… @IAVI
SARS-CoV-2 spike protein is readily vulnerable to neutralizing antibodies thankfully. But HIV Env protein has a protective cloak of sugar molecules, and mostly only weird-shaped antibodies produced by rare B cells can penetrate the cloak and neutralize HIV.
Inducing these weird antibodies with vaccines is a tough challenge, hence the lack of an effective #HIV vaccine. The @scrippsresearch @IAVI study is hopefully a first step toward boosting numbers of B cells that - with additional persuasion - can produce protective antibodies.
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