Unfortunately there's misinformation circulating about this #HIV vaccine study. It's not mRNA but protein, and there's no expectation of efficacy - it's a possible first step on a long road toward persuading B cells to make protective antibodies scripps.edu/news-and-event…@IAVI
SARS-CoV-2 spike protein is readily vulnerable to neutralizing antibodies thankfully. But HIV Env protein has a protective cloak of sugar molecules, and mostly only weird-shaped antibodies produced by rare B cells can penetrate the cloak and neutralize HIV.
Inducing these weird antibodies with vaccines is a tough challenge, hence the lack of an effective #HIV vaccine. The @scrippsresearch@IAVI study is hopefully a first step toward boosting numbers of B cells that - with additional persuasion - can produce protective antibodies.