Founding Director Olayan Center for Cancer Vaccines @MSKCancerCenter | Cancer Surgeon-Scientist | Pancreas cancer | Cancer immunology | 2x dad, 2x ironman
Feb 19 • 25 tweets • 7 min read
#mRNAvaccines for #PancreaticCancer (PDAC) PART4
1. Out today in @Nature
🧵👇🏽
[1/23]nature.com/articles/s4158…2. MAJOR BARRIER for Cancer Vaccines = How DO you make anticancer T cells of HIGH
- Magnitude
- Longevity
- Function
Can you teach T cells to recognize “self” ➕ persist ➕ function…
👇🏽 [1/32]
2. In 2017, we reported in @Nature here -> nature.com/articles/natur… -> that primary tumors of long-term survivors of #PDAC had ~12x more activated CD8 T cells vs. short-term survivors
AND
despite #PDAC’s few mutations, mutation-derived NAs may still be T cell antigens in #PDAC.
May 19, 2022 • 31 tweets • 19 min read
Today, in @Nature, we reveal PART 2 of our investigations on
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In 2017, we reported in @Nature here -> nature.com/articles/natur… -> that primary tumors of long-term survivors of #PDAC had ~12x more activated CD8 T cells vs. short-term survivors. Now, others had reported this before - but we wanted to know:
