Vinod BalachandranMD Profile picture
Cancer Surgeon-Scientist | Pancreas cancer | Lab = Cancer immunology | Husband, father | Food, language, 2x ironman @MSKCancerCenter
May 10, 2023 33 tweets 30 min read
1. ENTER #mRNAvaccines for #pancreaticcancer! Long-term #PDAC survivor story PART3.

"Do #PDACs REALLY have vaccine neoantigens (NAs)"? (aren’t they lowly mutated?)

If each patient = own NAs, how do you vaccinate?

Maybe mRNA? But how?

@Nature nature.com/articles/s4158…

👇🏽 [1/32] 2. In 2017, we reported in @Nature here -> nature.com/articles/natur… -> that primary tumors of long-term survivors of #PDAC had ~12x more activated CD8 T cells vs. short-term survivors

AND

despite #PDAC’s few mutations, mutation-derived NAs may still be T cell antigens in #PDAC.
May 19, 2022 31 tweets 19 min read
Today, in @Nature, we reveal PART 2 of our investigations on

“What IS going on in long-term survivors of #PancreaticCancer (#PDAC)?”

“Is it REALLY the immune system?”

Well…more evidence here - > nature.com/articles/s4158…

Thread below [1/30] In 2017, we reported in @Nature here -> nature.com/articles/natur… -> that primary tumors of long-term survivors of #PDAC had ~12x more activated CD8 T cells vs. short-term survivors. Now, others had reported this before - but we wanted to know:

“What are the antigens?” Image