Hey so let's say we are making a trans spider hero.

First thing we probably have to change is the loss of a caring parental figure do to their failure. Many trans kids just don't have one of those, so instead, a peer makes perfect sense. Found family, yknow?
#spidergwen Now, it's a spider story so, despite having all this great power, our trans hero learns that it comes with great responsibility, obviously.

So, when our hero fails to save her trans peer, her found family, she dedicates herself to that responsibility.

How might that manifest?