Thread 1/8: NEW @EJEndo paper out now from our group: Classic androgens and 11-oxygenated androgens in serum and saliva across adulthood: a cross-sectional study analysing the impact of age, body mass index, and diurnal and menstrual cycle variation academic.oup.com/ejendo/article… Thread 2/8: In the adrenal, androstenedione (A4) can be converted to 11-hydroxyandrostenedione (11OHA4), previously considered a dead-end metabolite. @KarlStorbeck showed that 11OHA4 is activated to 11-ketotestosterone (11KT), an androgen of equal potency to testosterone (T).

Mild Autonomous Cortisol Secretion (MACS) in benign adrenal tumours increases risk of hypertension and type 2 diabetes and predominantly affects women - read our latest research with @AnnalsofIM Author Video and Editorial acpjournals.org/doi/10.7326/M2… Thanks to all our collaborators from @ENSAT_news and praise for first author @AlePreteUoB and core team members @AliceSitch @anuradhaa_s @Nirantharakumar @Angela_E_Taylor @IrinaBancos @VChortis - read the associated press release @news_ub here birmingham.ac.uk/news/latest/20…

This is 1/14 of a thread summarising the major Arlt Lab outputs in this very special year, highlighting the Postdocs and PhD students delivering impactful work in most difficult circumstances - and all our fabulous collaborators around the globe! First 2020 output, spearheaded by visiting clinical research fellow Alberto Tresoldi with important contributions @DiabetesUK Sir George Alberti Fellow @AlePreteUoB - fabulous collaboration with @Nirantharakumar - read the paper #openaccess here academic.oup.com/jcem/article/1…

#1 New @IMSR_UoB @UoB_IAHR research: Urine steroid metabolomics for the differential diagnosis of adrenal incidentalomas: a prospective test validation study – learn all about the #EURINEACT study in this twitter thread and read its results #OpenAccess thelancet.com/journals/landi… #2 Cross-sectional imaging by CT or MRI regularly discovers adrenal masses; 2-12% are eventually diagnosed as adrenal cortical carcinoma #ACC . However, limited specificity of imaging prevents accurate detection of #ACC eje.bioscientifica.com/view/journals/…