Our new study just published in @CellRepMed shows that SARS-CoV-2 vaccine breakthrough infections (BTIs) have a positive effect on T cell responses! 1/8
@SetteLab @Alba_Grifoni @profshanecrotty @P1RAD @TertuAPN @LJIresearch cell.com/cell-reports-m…
BTIs boost vaccine-induced immune responses by increasing both the magnitude of response and the breadth of T cell antigens recognized. Effectiveness of the T cell response can be amplified by BTIs, contributing to more widespread immunity in the general population. 2/8

Can CD4+ T cells cross-recognize different coronaviruses (CoV), offering immune protection from potential future CoV pandemics? We explore this concept in our new study, just posted in pre-print. biorxiv.org/content/10.110…
@Alba_Grifoni @SetteLab 1/5 We map the targets of T cell reactivity to 2 recurrent CoV that can cause the common cold (NL63 and OC43) and identify 6 immunodominant antigens, of which Spike, Membrane, Nucleocapsid, nsp3 and nsp12 were also prominently recognized in SARS-CoV-2. 2/5

Our paper investigating CD4 T cell responses in #acute #COVID-19 patients was just published: mdpi.com/1422-0067/23/1…. (1/4)

Great collaboration between US and Italian institutes: @SetteLab @Alba_Grifoni @GFilaci @MarioU_Mondelli @CarlaEMontesano In a sizable cohort of 89 acute patients, milder COVID-19 associated with early CD4 responses detected by both AIM and IFNg ICS. This confirms earlier studies with more limited patient numbers, and highlights the key relation of timing of CD4 responses to disease outcomes. (2/4)