Alice Chen-Plotkin Profile picture
Neurologist-neuroscientist at the University of Pennsylvania. Mom (of two), wife (of one).
Apr 23, 2023 7 tweets 3 min read
Cognitive heterogeneity in Parkinson’s disease: A mechanistic view cell.com/neuron/fulltex…

Our thoughts on #synuclein strains, #Alzheimer pathology, and individual genetic and biomarker characteristics in why individuals with #Parkinson disease manifest so differently. 1/n We review how cognition looks in #Parkinsons (short answer: lots of different ways in different people). We review treatment options for cognitive impairment in PD (short answer: not many). We argue that mechanistic focus is needed for better treatment options to emerge. 2/n