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Anurag Adhikari, PhD Profile picture
Anurag Adhikari, PhD
@anura_Adhikari
Innate-B cell Immunologist working on T cells.
Apr 26, 2021 • 9 tweets • 3 min read
#new paper in SARS-CoV-2 innate immunity
Pre-print in #bioRxiv

We found, SARS2 viral load and antiviral responses in nasal epithelium wane with advancing age, but Viral load alone is unlikely to explain differences in IFN induction observed.
biorxiv.org/content/biorxi…
thread/ 1/
 We infected differentiated nasal epithelium cultures derived from healthy children (1-12 y/o), young adults (26-34 y/o) and older adults (56-62 y/o) with SARS2 to identify age-related cell-intrinsic differences that may influence viral entry, replication and host response