Our latest SARS-CoV-2 serosurveillance data for England with @NHSBT (Oct-Dec 2022) is now out in the @UKHSA vaccine surveillance report.

Anti-nucleocapsid seropositivity: 82.5 % (c/f 78.2%)
Anti-spike seropositivity: 99.9% (c/f 99.8%)

gov.uk/government/pub… London still holds the crown 👑 for highest seropositive region at a whopping 88.5%, but all regions showing increases and likely to go higher after Christmas increase

After a brief hiatus...our SARS-CoV-2 serosurveillance data is now updated in the @UKHSA vaccine surveillance reports: gov.uk/government/pub…

Main thing you'll see is just shy of 70% of individuals have evidence of prior infection (positive for anti-nucleocapsid antibodies) 👇 When we split this by age, we see that younger groups (17-29 and 30-39) almost ~80% have been infected, whilst older age groups are lower, but generally all groups have shown a steady increase since Omicron emerged

New #SIREN🚨 preprint out (and also being presented at #ECCMID2022 this week)...we did a cross-sectional analysis of ~6,000 SIREN participants after their vaccinations

Thread on our results and few interesting ones...🧵

medrxiv.org/content/10.110… @UKHSA @SMHopkins First up, SIREN is an incredibly big research project...so we were able to select samples from participants that provided a baseline sample (done when enrolled into SIREN) but after they were vaccinated, giving us an initial pool of ~6,000 participants...