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Na Cai Profile picture
Na Cai
@caina89
PI at @PioneerCampus @CompHealthMuc @HelmholtzMunich working on depression genetics
Aug 16, 2022 • 18 tweets • 7 min read
New preprint! In this paper @andywdahl and I et al show how phenotype integration can improve GWAS power and PRS prediction for Major Depressive Disorder (MDD), and a new and simple metric for quantifying how specific these improvements are for MDD tinyurl.com/mry37nry
🧵 1/n Bit of context: in 2020 we published a paper saying minimal phenotypes widely collected in biobanks and EHRs (eg self-reported depression, ICD10 codes) do not capture specific genetic effects for MDD, old tweetorial here:
2/n
Aug 23, 2021 • 12 tweets • 10 min read
New paper in @NatureMedicine on #mtDNA variant effects on metabolites, from my colleagues and I from @sangerinstitute, @emblebi , @Cambridge_Uni and @MRC_MBU! nature.com/articles/s4159…

@nicolesoranzo @cam_mito @OliverStegle @auroradevea @joannahowson @DoingYonova
🧵 1/n We identified common #mtDNA variants in 16K British individuals with EUR ancestry from the INTERVAL study, performed the first large-scale assoc study between #mtDNA variants and ~5000 molecular traits that directly tag metabolic processes. 2/n