If you see saddlepoint approximation used in genomics, @weizhouw introduced the concept to fellow @umich grad student @ellenmschmidt ~2012/2013 when we developed GREGOR - a method for assessing significance of enrichment of overlap between a genomic feature and GWAS hits
This allowed us to avoid deep permutation to estimate really small (significant) p-values
Sep 25, 2020 • 7 tweets • 3 min read
Science has a history of treating Black Americans and other minority ancestry groups badly. We, as genetics scientists, are working hard to make it right & ensure research also benefits ancestry minorities. a thread #BlackLivesMatter#blackinstem#IndigenousLivesMatter
To do that, we are asking and inviting minority ancestry groups to join genetics research studies (that also include majority ancestry groups fyi). We are dedicated to (and good at) protecting confidentiality and ensuring anonymity. 2/6