Hanging out daydreaming (lolz) in the sleep and circadian panel session at #INSAR2019 #circadianrhythms #sleepwakecycle #timeisasocialconstruct #exceptwhenitsbiobasedandinyourbody #sleepdependent Sleep in those with Tuberous sclerosis have changed in the mTOR pathway that can make or brake translation of protein synthesis. Turns out that causes wonky circadian rhythms. AND changing BMAL1 ("a core clock driver") levels got sleep cycles back in order.