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Dr. Gennadi Glinsky, MD, Ph.D. Profile picture
Dr. Gennadi Glinsky, MD, Ph.D.
@gglinskii
Posts are my own immediate personal reflections on current events or views expressed by others. Retired. Professor, Translational and Functional Genomics.
Dec 2, 2021 • 9 tweets • 4 min read
Omicron mutations
1. Immunoselection K427N; G446S; E484A
2. Proliferation in immunosuppressed patients
NTD deletions around 144, 478K, 484A, 501Y
3. Adaptation to in vitro culture
H655Y
4. Hijacking of host sequences
Presence of host derived RNA insertion from human TMEM245 gene @jbloom_lab noted
that Omicron has 3 mutations in Spike that are strongly associated with antibody selection in humans (K427N; G446S; E484A). Thus, it has been suggested that immune selection pressure was one of the contributing forces to the evolution of the Omicron.
Dec 2, 2021 • 5 tweets • 3 min read
1. Immunoselection step. @jbloom_lab noted that Omicron has 3 mutations in Spike that are strongly associated with antibody selection in humans (K427N; G446S; E484A). Thus, immune selection pressure was one of the contributing forces to the evolution of the Omicron. K417, E484 & G446 were among sites of strongest escape from each of 3 classes of RBD antibodies. When @AllieGreaney @tylernstarr trying to pick mutations w biggest effect on antibody escape, they picked those sites (2/2)
Dec 1, 2021 • 6 tweets • 2 min read
Paper number one. Paper number two.
Oct 28, 2021 • 7 tweets • 2 min read
Some of distinguishing features of this contagion that make the eventual outcomes uncerain: 1. Relatively high prevalence of #LongCovid, including brain pathology-related didorders; this phenomenon has been documented even in patients with mild disease; 2. Nearly ubiquitous expression in human body of the receptor for virus entry in human cells, ACE2; among other, notable target cells range from salivary gland, brain, endothelial & immune cells; male germ cells;
Oct 24, 2021 • 14 tweets • 5 min read
Single cell genomics & epigenetics identify stem cell like cancers: Genomics-Guided Drawing of Molecular and Pathophysiological Components of Malignant Regulatory Signatures Reveals a Pivotal Role in Human Diseases of Stem Cell-Associated Retroviral frontiersin.org/article/10.338… Single cell genomics & epigenetics studies highlight limitations of a prevailing concept viewing all cancers as mutations-initiated/mutations-accumulating slowly progressing malignancies. frontiersin.org/article/10.338…