Machine learning, genomics, cancer immunotherapy, personalized vaccines. @CompMedUNC @UNC_Lineberger @OpenVax
Feb 25 • 19 tweets • 6 min read
Preprint live: biorxiv.org/content/10.110…
tl;dr We did not disprove the role of T-cells in clearing SARS-CoV-2 (sorry to disappoint) but we did manage to make a vaccine which induces strong but useless T-cell responses against SARS-CoV-2. Details & guess at interpretation below 1/n
Many SARS-CoV-2 vaccines present the immune system with the spike protein or the parts of the spike most vulnerable to neutralization (S1 portion or even just the RBD). This antigenic content can be made directly (protein subunit), encoded as mRNA, DNA, DNA in a virus, &c
Jun 15, 2021 • 26 tweets • 12 min read
It's been a preprint for a while but a much improved version of our paper is out in @GenomeMedicine
"Landscape and selection of vaccine epitopes in SARS-CoV-2"