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Jason Wong Profile picture
Jason Wong
@jasonwwong
Associate Professor at the School of Biomedical Sciences, University of Hong Kong. Uses genomics data to understand DNA repair and cancer.
Nov 19, 2020 • 9 tweets • 4 min read
Excited to share our latest preprint titled "Deficiency in DNA mismatch repair of methylation damage is a major mutational process in cancer" biorxiv.org/content/10.110… #Cancer #DNARepair MMR is well known for its role in the repair of mismatched base pairs that escape proof-reading by replicative DNA polymerases. However, more than 4 mutational signatures have been associated with MMR deficient cancers. What are their underlying processes?