Here' my "n=1 / anecdote / was clearly bored" symptom diary of my #breakthrough #COVID19 case. And a short thread on things I found interesting about the disease process. (1/n)

https://twitter.com/jschoggins/status/1435231333006053377

My symptoms were not unique or special. They generally tracked with other reports on breakthrough delta infection in Isreal, Singapore, and US. Link to CDC report on Provincetown outbreak below as an example. (2/n)

cdc.gov/mmwr/volumes/7…

Taking a detour from all things interferon to present work on a non-interferon based restriction factor. Postdoc @Wenchun_Fan discovered TRIM7 as a potent inhibitor of multiple human enteroviruses. Now out in @CellPressNews @UTSWNews
authors.elsevier.com/a/1d9saL7PXe%7…
1/7 Through virologic, biochemical, and cell biological approaches, Wenchun found that TRIM7 functions as an E3 ligase that targets enterovirus 2BC for ubiquitination and proteasome-dependent degradation. This wipes out viral replication. 2/7

Never thought we’d contribute to clinical trial for COVID-19, but here we are. With @HeshamS70605263 team, we found FDA-approved drugs that curb SARS-CoV-2 in cells. Clinical trial pending approval. Study in Chemrxiv. Details in thread. 1/10
doi.org/10.26434/chemr… via @figshare Here’s how it happened. @HeshamS70605263 team used computers (‘molecular docking’) to find FDA-approved drugs that might target a SARS-CoV-2 protein. Like a key fitting into a lock. If the drug fit, it might hinder the virus. 2/10