Cancer genomics, epigenomics and evolutionary dynamics (Weill Cornell/New York Genome Center). Hemato-oncologist (NYP). Discl.: https://t.co/tAu87FMVW3
May 12 • 18 tweets • 12 min read
💃📢¡GoTChA! New pre-print🤯🕺
High throughput single-cell multi-omics platform to jointly capture genotype and chromatin accessibility; charting the differentiation of clonal outgrowths
If you have a moment, would love to tell you all about it 👇
Clonal outgrowths are everywhere in us humans. In malignant and non-malignant tissue. But we know little about the phenotypes of somatic driver mutations in primary human samples. To address this key challenge we need the ability to connect genotype and phenotype in single cells
Excited to share our work @NatureMedicine offering a novel framework [MRDetect] for ultra-sensitive cancer monitoring through whole genome mutational integration of cfDNA go.nature.com/2XmxJZv 1/ #LiquidBiopsy#WGS#cfDNA#MachineLearning
Therapy monitoring is a central pillar of modern medicine. And yet, in many areas of oncology, we lack sensitive monitoring tools for residual disease detection. ctDNA carries the potential to change this, but is scarce in low-burden disease.