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Laura Huppert, MD Profile picture
Laura Huppert, MD
@laura_huppert
Breast cancer oncologist @UCSF | Interested in breast cancer clinical/translational research, med ed | Author of Huppert’s Notes | Tweets my own
Aug 16, 2022 • 20 tweets • 25 min read
@TumorBoardTues @hoperugo 1/20 #TumorBoardTuesday #BCSM #OncTwitter

CASE: 54yo post-menopausal 👩 with HR+/HER2- (IHC 1+, 🐠FISH neg) MBC who had disease progression on 3 lines of endocrine/targeted rx, then capecitabine.

Scans show progression in liver.

🤔 What therapy would you use next? @TumorBoardTues @hoperugo 2/20 #TumorBoardTuesday

What is HER2-low #BreastCancer?
🔹 HER2 IHC 1+ or 2+/ISH neg
🔹 Large % of HR+ BC (~67%), less in TNBC
🔹 Prognosis/biology indistinct from HER2-0
🔹 Unreliable IHC scoring; need better tests!
🔹 NOT a BC subtype; but targetable

tinyurl.com/2p89vteh
May 10, 2021 • 8 tweets • 6 min read
#MedTwitter I’m excited to share a project near and dear to my ❤️ : Huppert’s Notes!

amazon.com/Hupperts-Notes…

A thread 🧵... Image When I was a med student, I loved internal medicine but I couldn’t find a resource to help clearly organize the vast amount of information… so I started taking my own notes. I added to them throughout residency and they became my external brain: everything I knew about IM!