@jmcdonou and I are excited to share our findings in our manuscript "Characterization of the COPD alveolar niche using single-cell RNA sequencing" disq.us/t/44nd2rt, finally out @NatureComms. Follow the 🧵for more details. COPD is a leading cause of death and a major risk factor for infectious and chronic systemic disease. Despite significant progress, a cell-type specific understanding of disease pathobiology is lacking. So we analyzed scRNAseq results of 15 control and 17 advanced COPD lungs.

Excited to share our work using single-cell RNA sequencing to profile the lung parenchyma in advanced COPD. Follow 🧵for highlights and new #COPD insights medrxiv.org/content/10.110… Manuscript is co-authored with @jmcdonou, w/ leadership from @KaminskiMed @YalePCCSM and Ivan Rosas @bcmhouston and important contributions from Taylor Adams, Neeha Kothapalli @Yale @ptimshel @jonas_schupp @caroymalo @JLGomezMD @SergioPoli @mauchioccioli & others not on twitter